Shellfish disease introduction is a concern for shellfish farmers, fishers, and resource managers worldwide. At the center of the rapidly expanding shellfish culture footprint is the hatchery production of seed. Interstate seed transfers, crucial for industry growth, are currently regulated by individual states, but shellfish disease distributions do not follow state boundaries. The purpose of the RSSBP is to facilitate the process for permitting interstate commerce of biosecure bivalve shellfish seed and larvae being sold directly out of hatchery facilities. The RSSBP Core Elements provide a science-based pathway to improved biosecurity.